What it is

A tripeptide fragment of alpha-MSH (Lysine-Proline-Valine), studied extensively for anti-inflammatory effects in skin and gut barrier research.

Why it's studied

KPV modulates inflammatory pathways without immunosuppression — a mechanism distinct from traditional anti-inflammatory compounds. Research has focused on inflammatory bowel models and skin barrier integrity.

Key research findings

• Downregulation of TNF-α and IL-6 in inflammatory bowel research (Kannengiesser et al.)

• Improved gut barrier integrity in colitis animal models

• Demonstrated anti-inflammatory effects in skin tissue research