A small-molecule inhibitor of NNMT (nicotinamide N-methyltransferase) — an enzyme upregulated in obese adipose tissue and linked to metabolic dysfunction.
5-Amino-1MQ is one of the few compounds in metabolic research that targets adipose tissue directly via NNMT inhibition — a mechanism distinct from every GLP-1 or GHRH compound.
Significant fat mass reduction without changes to food intake (Neelakantan et al., diet-induced obesity model)
Preserved muscle mass during fat loss in animal models
Documented NNMT inhibition restoring NAD+ and SAM cellular pools